1949年12月7日Tom Waits出生于加州波摩那，最大的外在特征是他那张永远离不开烟的脸和提着酒罐的手，计程车司机的气质和加州中下阶层小人物的身影。Waits从小酷爱Cool Jazz的萨克斯风音乐，同时他也热爱60年代的西岸摇滚音乐，如Bing Grosby、George Gershwin的节奏蓝调，到The Beach Boys的冲浪摇滚和The Grateful Dead的迷幻摇滚。在这个Tom成长的时代中，对他内在影响深远的莫过于"垮掉的一代"的文学作家Jack Kerouac和Charles Bukowski的作品了。青少年时期，Tom在洛杉矶的午夜俱乐部打工，为客人开车门、看店门挣些生活费，这种环境令他立志总有一天他要成为门内的表演者的意向。直到1969年他终于在洛城一家名为Troubador的俱乐部达成他的心愿，做了第一场演出。并获得实验摇滚乐队Frank Zappa的经纪人Herb Cohan的欣赏，作为Tom的经纪人，让他进入摇滚巨星的表演圣地Tropicana大饭店演出。这段时间TomWaits建立起广大的乐迷基础，遂于1972年和隶属于华纳公司旗下的重镇Elektra/Asyium唱片公司签约。1973年的处女作Closing Time问市，其中单曲"OL'55"被收入Eagles乐队同年专辑On The Border中，评价很高，但Tom的Closing Time却卖的其惨无比。
Tom的音乐初听者是不会喜爱的，在他的音乐中配器与录音是十分简陋的。这还不算，他的歌声更是非同小可地令人难安，一种喉痛声哑的吟喃，像是酗酒过多或噎住一口陈年老痰般地破铜嗓子。乍听之下是种病痛与听觉虐待的难安，习惯后，却成了煽情感动的难安。很Jazzy的感伤和氛围，形成了Tom的音乐世界。烟酒不离的印象，搭配着描述卑下社会颓废景状的歌词，使Tom的音乐和内容宛如一面镜子般的反映出洛城"最深层面人们的生活面貌，整个70年代的洛城，在Tom Waits的描述中，呈现出最一般性的存在。
In the 1970s, Tom Waits combined a lyrical focus on desperate, lowlife characters with a persona that seemed to embody the same lifestyle, which he sang about in a raspy, gravelly voice. From the '80s on, his work became increasingly theatrical as he moved into acting and composing. Growing up in southern California, Waits attracted the attention of manager Herb Cohen, who also handled Frank Zappa, and was signed by him at the beginning of the 1970s, resulting in the material later released as The Early Years and The Early Years, Vol. 2. His formal recording debut came with Closing Time (1973) on Asylum Records, an album that contained "Ol' 55," which was covered by labelmates the Eagles for their On the Border album. Waits attracted critical acclaim and a cult audience for his subsequent albums, The Heart of Saturday Night (1974), the two-LP live set Nighthawks at the Diner (1975), Small Change (1976), Foreign Affairs (1977), Blue Valentine (1978), and Heart Attack and Vine (1980). His music and persona proved highly cinematic, and, starting in 1978, he launched parallel careers as an actor and as a composer of movie music. He wrote songs for and appeared in Paradise Alley (1978), wrote the title song for On the Nickel (1980), and was hired by director Francis Coppola to write the music for One from the Heart (1982), which earned him an Academy Award nomination. While working on that project, Waits met and married playwright Kathleen Brennan, with whom he later collaborated.
Moving to Island Records, Waits made Swordfishtrombones (1983), which found him experimenting with horns and percussion and using unusual recording techniques. The same year, he appeared in Coppola's Rumble Fish and The Outsiders, and, in 1984, he appeared in the director's The Cotton Club. In 1985, he released Rain Dogs. In 1986, he appeared in Down By Law and made his theatrical debut with Chicago's Steppenwolf Theatre in Frank's Wild Years, a musical play he had written with Brennan. An album based on the play was released in 1987, the same year Waits appeared in the films Candy Mountain and Ironweed. In 1988, he released a film and soundtrack album depicting one of his concerts, Big Time. In 1989, he appeared in the films Bearskin: An Urban Fairytale, Cold Feet, and Wait Until Spring. His work for the theater continued in 1990 when Waits partnered with opera director Robert Wilson and beat novelist William Burroughs and staged The Black Rider in Hamburg, Germany. In 1991, he appeared in the films Queens' Logic, The Fisher King, and At Play in the Fields of the Lord. In 1992, he scored the film Night on Earth; released the album Bone Machine, which won a Grammy Award for Best Alternative Music Album; appeared in the film Bram Stoker's Dracula; and returned to Hamburg for the staging of his second collaboration with Robert Wilson, Alice. The The Black Rider was documented on CD in 1993, the same year Waits appeared in the film Short Cuts.
A long absence from recording resulted in the 1998 release of Beautiful Maladies, a retrospective of his work for Island. In 1999, Waits finally returned with a new album, Mule Variations. The record was a critical success, winning a Grammy for Best Contemporary Folk album, and was also his first for the independent Epitaph Records' Anti subsidiary. A small tour followed, but Waits jumped right back into the studio and began working on not one but two new albums. By the time he emerged in the spring of 2002, both Alice and Blood Money were released on Anti Records. Blood Money consisted of the songs from the third Wilson/Waits collaboration that was staged in Denmark in 2000 and won Best Drama of the year. After limited touring in support of these two endeavors, Waits returned to the recording studio and issued Real Gone in 2004. The album marked a large departure for him, in that it contained no keyboards at all, focusing only on rhythm-stringed instruments.