Murphy Lee出生在美国密苏里州的St. Louis市，家里有一个哥哥KyJuan，KyJuan是美国著名的南方说唱歌手Nelly的好朋友。Murphy Lee从小就是跟着哥哥KyJuan一起玩的，小时候，Murphy Lee还是一个中规中距的好学生，平时认真学习，课余时间打打篮球，但是逐渐的受到了哥哥和他的朋友们的影响，Murphy Lee把注意力逐渐转移到了音乐上来。后来他就跟着Nelly以及Nelly和他的高中朋友们一起组建的the St. Lunatics乐团一起搞说唱。随后的生活中，说唱音乐就成为了Murphy Lee生活中的最重要的部分，他开始在Nelly的身边工作，不久就获得了录音的机会，从2000年Nelly的销量突破九白金的首张个人专辑《Country Grammar》开始，Murphy Lee就频繁的出现在Nelly和其他说唱歌手的专辑录制现场。Murphy Lee先后参与录制了the St. Lunatic乐团2001年的白金专辑《Free City》以及Nelly在2002年发行的专辑《Nellyville》，那张专辑的销量超过了600万张，在今年的动作大片《绝地战警2(Bad Boys 2)》的原声碟中，他还协助Nelly和P. Diddy共同录制了其中的单曲《Shake Ya TailFeather》。2003年9月23日，Murphy Lee发行了第一张个人专辑《Murphy's Law》。(CatCobain) by Johnny LoftusThe St. Lunatics crew had been a fixture in its native St. Louis since the early '90s, scoring regional hits and continuing to develop its unique Midwestern spin on the Dirty South dynamic. But while they had secured management and a major-label deal, nothing materialized until the multi-platinum success of Lunatics member Nelly's 2000 solo effort. The margins of Country Grammar had been filled with guest shots from the Lunatics, including Murphy Lee. His style was in keeping with Nelly's little-bit-country, little-bit-city flow, but he stood out with a more nasally sound, and raps that were somehow wordy and laid-back all at once. With their name established on the national scene, Murphy Lee, Nelly, and rest of the St. Lunatics dropped their official debut in June 2001. Free City was a hit, but not of the caliber of 2002's Nellyville. The latter album was another phenomenal success for Nelly, and featured Murphy Lee on a few tracks, including the strong Roc-a-Fella collaboration "Roc the Mic" and the fun hit single "Air Force Ones." Murphy's profile received another boost in June 2003, when he joined Nelly and P. Diddy for "Shake Ya Tailfeather," the inescapable single from the Bad Boys II soundtrack. That momentum carried through to autumn and the arrival of his debut solo album, naturally entitled Murphy's Law. The set featured "Tailfeather," as well as the Jermaine Dupri-produced first single, "What da Hook Gone Be." Murphy started 2004 strong, sharing in a Best Rap Performance by a Duo or Group Grammy nod for "Tailfeather."